Several catalytic families of DNA enzymes (deoxyribozymes) have previously been isolated through the use of an in vitro selection technique in our laboratory. The activities of these deoxyribozymes appear to be dependent ...
Certain 4-alkylamino-1,8-naphthalimides have been used as photosensitizers for photochemical protein crosslinking. In my research various types of 4-amino and N-substituents naphthalimides have been synthesized and studied ...
The goal of the primary project was to explore further means of meniscal repair through application of the immobilization techniques previously developed by our research group. The menisci are susceptible to tears due to ...
One of the main goals of the primary project was to develop methods to site specifically immobilize functional proteins on a tissue surface. There are many examples of proteins that have been chemically modified and ...
Our lab has long had an interest in the potential biomedical applications of naphthalimide photochemistry, including especially the use for the bonding and modification of fresh tissue. Photochemical tissue bonding represents ...
Protected amino thymidines were synthesized as part of a project aimed at developing reagents for the site-specific, sequence selective DNA cleavage. Modified DNA oligonucleotides have the capacity to behave like artificial ...
Over the past 10 years a number of catalytically active single-stranded DNA molecules (deoxyribozymes) have been isolated from combinatorial libraries (pools) of randomized oligonucleotides. These enzyme-like DNAs customarily ...