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Browsing Theses/Dissertations - Chemistry & Biochemistry by Issue Date

Browsing Theses/Dissertations - Chemistry & Biochemistry by Issue Date

Now showing items 1-20 of 52

Unique fragmentation of pentafluorobenzylic alcohols and the use of modified injection port liners in the gas chromatographic-based screening for catalytic activity.

Fisher, Henry C.

An unprecedented reaction, the base-catalyzed fragmentation of pentafluorobenzylic alcohols, was investigated. Studies on a variety of C6F5-derived alcohols show that a dual reaction pathway occurs in mixed solvent systems ...
Modification of fresh tissue surfaces; synthesis of labeled L-dopa analogs; and synthesis of metoclopramide analogs.

Perera, Aruna B.

One of the main goals of the primary project was to develop methods to site specifically immobilize functional proteins on a tissue surface. There are many examples of proteins that have been chemically modified and ...
Luminescent supramolecular silver(I) coordination complexes of pyridyl-substituted phosphinites, phosphonites and amines.

Feazell, Rodney P.

Interest in the design and synthesis of supramolecular metal-organic coordination polymers has increased exponentially in the last decade. This attraction comes along with advances in crystallographic instrumentation that ...
Design, synthesis and biological evaluation of new anti-Cancer nitrogen-containing combretastatins and novel cysteine protease inhibitors for the treatment of Chagas.

Siles, Rogelio.

In an effort to combat cancer, the development of a relatively new type of anti-cancer drugs known as vascular disrupting agents (VDAs) seems to be a promising clinical approach. VDAs selectively interfere with blood flow ...
Structure-activity relationships and thermodynamics of combretastatin A-4 and A-1 derivatives as potential inhibitors of tubulin polymerization.

Mugabe, Benon E.

Inhibition of tubulin polymerization has been identified as a significant characteristic of potential anticancer agents. Tubulin is a heterodimeric protein of a and b polypepetide chains, each with a molecular weight of ...
Discovery and development of unique small molecule chromene based ligands and combretastatin analogs as potential second generation vascular disrupting agents towards cancer chemotherapy.

Arthasery, Phyllis.

Cancer is a devastating disease, which remains one of the leading causes of death worldwide. In our continuing quest to help find a cure for cancer, we have discovered and developed new small molecule vascular disrupting ...
A novel spectropolarimeter for determiation of sucrose and other optically active samples.

Calleja-Amador, Carlos Enrique.

Polarimetry and spectropolarimetry are important tools in the sugar industry and pharmaceutical research. Polarimetric measurements cannot be performed on colored samples because the presence of color interferes with the ...
Design, synthesis and biological evaluation of novel serotonin reuptake inhibitors and novel derivatives of a nitrogen-containing combretastatin analog.

Miranda, Maria Graciela.

Depression is a common and serious illness that affects one out of every ten Americans each year. Since the 1980's, selective serotonin reuptake inhibitors (SSRIs) have been the pharmaceuticals of choice for the treatment ...
Studies on regression modeling of spectral data as a means of chiral analysis.

Ingle, Jemima Rose.

The enantiomeric composition of samples was determined using spectroscopy and multivariate regression modeling. Partial least-squares (PLS-1) regression models were developed from the spectral data of solutions containing ...
Determination of pharmaceuticals and personal care products in fish using high performance liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry.

Ramirez, Alejandro Javier. (Washington, DC : American Chemical Society Publications., )

Labeled as emerging organic contaminants, pharmaceuticals and personal care products (PPCPs) have been the focus of global environmental research for over a decade. PPCPs have caused widespread concern due to their extensive ...
Electrochemistry and electron transfer induced substitution reactions of methylcyclopentadienylmolybdenum tricarbonyl complexes and electrospray ionization mass spectrometry and x-ray crystallographic characterization of related molybdenum complexes.

Munisamy, Thiruvengadam. (Oxford, UK : Elsevier, )

The complexes Cp'Mo(CO)3X (X = Cl, Br, I; Cp' = C5H4CH3) and [Cp'Mo(CO)3(L)]+ (L = CH3CN, CH3COCH3) were synthesized and their electrochemistry and electron transfer induced substitution reactions were studied. Electrochemical ...
Synthetic coenzymes for in vitro selection of DNA enzymes.

Carranza, Dorn L.

Over the past 10 years a number of catalytically active single-stranded DNA molecules (deoxyribozymes) have been isolated from combinatorial libraries (pools) of randomized oligonucleotides. These enzyme-like DNAs customarily ...
Vibrational spectroscopy in cryogenic solutions: application of thermal lensing and Fourier transform techniques to the study of molecular C-H overtone transitions.

Lopez-Calvo, Alfredo.

This dissertation explores the application of thermal lensing to vibrational overtone spectroscopy in cryosolutions. Specifically, C-H (delta v = 6) overtone spectra of hydrocarbons dissolved in liquefied rare gases are ...
Studies on the application of laser photoionization in supersonic-jets for the generation of intense ionic clusters.

Navea, Juan G.

Pulsed photoionization in a supersonic expansion was investigated for the production of intense ionic cluster beams from seeded organic molecules. Neutral clusters were photoionized in a pulsed system and studied by means ...
Studies on bovine γ-glutamylamine cyclotransferase.

Roca, Maryuri.

The purification and study of proteins are cooperative processes because at least partially purified protein is needed in order to study its properties, and certain information about the protein's properties is required ...
Design and synthesis of dihydronaphthalene vascular disrupting agents and indolequinone-based bioreductives.

Dogra, Abhishek.

Cancer remains a deadly affliction for millions across the United States, and the number of new cases is only expected to rise in the years to come. In the field of anticancer research, vascular disrupting agents (VDAs) ...
Synthesis, characterization, and applications of redox-mediated ion exchangers.

Feazell, Monica N.

The technology for conversion of lignocellulosic biomass resources to fuels and chemicals has been under development for decades. There are many process configurations for conversion of biomass to ethanol, one of the ...
Ion-exchange and electrochemical properties of tetra-t-alkylferrocenium monolayers on gold electrodes.

Parisi, Natali.

Five penta-substituted ferrocenes, each having one 11-SH-undecanoyl substituent, have been prepared from 1,1′,3,3′-tetra-t-alkylferrocenes and attached as electrochemically-assembled monolayers to gold electrodes (t-alkyl ...
Chemistry, electrochemistry and electron transfer induced reactions of cobalt complexes with fluorinated ligands.

Gunawardhana, Kihanduwage N.

The chemical or electrochemical reduction of the trifluoroacetyl complex CF3COCo(CO)3PPh3 involves a single electron transfer yielding trifluoromethyl radical and an anionic cobalt carbonyl complex. The mechanism is ...
Design, synthesis and evaluation of di-nitrogen derivatives of combretastatin and novel cruzain inhibiting compounds for the treatment of Chagas disease.

Ackley, J. Freeland.

Over the past years cancer statistics have continued to rise to the point that the World Health Organization said that in 2005 cancer was leading cause of death worldwide. Years of research have resulted in many new ...