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Browsing Theses/Dissertations - Chemistry & Biochemistry by Title

Browsing Theses/Dissertations - Chemistry & Biochemistry by Title

Now showing items 1-20 of 52

Chemistry, electrochemistry and electron transfer induced reactions of cobalt complexes with fluorinated ligands.

Gunawardhana, Kihanduwage N.

The chemical or electrochemical reduction of the trifluoroacetyl complex CF3COCo(CO)3PPh3 involves a single electron transfer yielding trifluoromethyl radical and an anionic cobalt carbonyl complex. The mechanism is ...
Chemometric modeling of UV-visible and LC-UV data for prediction of hydrolysate fermentability and identification of inhibitory degradation products.

Hedayatifar, Negar. (, )

Production of ethanol from lignocellulosic biomass requires a pretreatment step to liberate fermentable sugars trapped within the plant. During pretreatment, lignin and some sugars undergo degradation to form compounds ...
Construction and calibration of a custom time-of-flight mass spectrometer and its use in measuring the reaction kinetics of transition metal ion-organic interactions.

Castleberry, Vanessa A.

A unique instrument was constructed and used to generate and interrogate jet cooled neutrals, ions and their respective clusters. The instrument is a result of the artful marriage of supersonic expansions combined with ...
Decarbonylation, reductive electrochemistry and x-ray crystal structures of some rhodium diphosphine acyl complexes.

Panthi, Basu Dev.

Acyl complexes of rhodium(III) with chelating diphosphine ligands (P-P = 1,3- bis(diphenylphosphino)propane and others) are well known for their stability toward decarbonylation. Various rhodium diphosphine acyl complexes ...
Design and synthesis of combretastatin A-1 analogs, small molecule vascular disrupting agents, and bioreductive triggers as potential therapeutic agents for the treatment of cancer.

Nguyen, Benson Lee.

Cancer is the second leading cause of death in the United States with over 550,000 deaths in 2009 and a devastating 7.9 million deaths worldwide in 2007. Vascular disrupting agents (VDAs) represent a novel method developed ...
Design and synthesis of dihydronaphthalene vascular disrupting agents and indolequinone-based bioreductives.

Dogra, Abhishek.

Cancer remains a deadly affliction for millions across the United States, and the number of new cases is only expected to rise in the years to come. In the field of anticancer research, vascular disrupting agents (VDAs) ...
Design and synthesis of functionalized small-molecule inhibitors of cathepsins L and K.

Jones, Lindsay M. (, )

Inhibition of a class of cysteine proteases known as the cathepsins has received increasing attention in recent years, since these enzymes play key roles in cancer metastasis. Cathepsins B, K, and L have been of particular ...
Design and synthesis of non-peptidic thiosemicarbazone derivatives as inhibitors of cathepsins L and K.

Song, Jiangli.

Cathepsin L, a member of the lysosome cysteine proteases, is ubiquitously expressed in tissue and is responsible for protein turnover. An overexpression of cathepsin L by certain tumor types is associated with enhanced ...
Design and synthesis of novel β-cyclodextrins and their application as chiral stationary phases for gas chromatography.

Hayden, Tiffany Renee Turner.

Enantiomers can be directly separated only with use of systems containing a chiral selector. Cyclodextrins (CDs) and modified cyclodextrins have been used as chiral selectors for their ability to form host-guest complexes ...
Design and synthesis of potential serotonin-selective reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors for the treatment of depression.

Elguézabal-Torralba, Gerardo Arturo.

Depression is a common disease characterized by feelings of deep sadness, guiltiness, loss of interest in once pleasurable activities, and thoughts of self-harm among others. Affecting an estimated 121 million people ...
Design, synthesis and biological evaluation of new anti-Cancer nitrogen-containing combretastatins and novel cysteine protease inhibitors for the treatment of Chagas.

Siles, Rogelio.

In an effort to combat cancer, the development of a relatively new type of anti-cancer drugs known as vascular disrupting agents (VDAs) seems to be a promising clinical approach. VDAs selectively interfere with blood flow ...
Design, synthesis and biological evaluation of novel serotonin reuptake inhibitors and novel derivatives of a nitrogen-containing combretastatin analog.

Miranda, Maria Graciela.

Depression is a common and serious illness that affects one out of every ten Americans each year. Since the 1980's, selective serotonin reuptake inhibitors (SSRIs) have been the pharmaceuticals of choice for the treatment ...
Design, synthesis and evaluation of di-nitrogen derivatives of combretastatin and novel cruzain inhibiting compounds for the treatment of Chagas disease.

Ackley, J. Freeland.

Over the past years cancer statistics have continued to rise to the point that the World Health Organization said that in 2005 cancer was leading cause of death worldwide. Years of research have resulted in many new ...
Design, synthesis, biochemical and biological evaluation of benzocyclic and enediyne analogs of combretastatins as potential tubulin binding ligands in the treatment of cancer.

Sriram, Madhavi.

One out of four deaths per day in the United States will be caused by cancer in the year 2007. Cancer still remains the second major cause of mortality both in developed as well as developing countries. Small molecule ...
Determination of pharmaceuticals and personal care products in fish using high performance liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry.

Ramirez, Alejandro Javier. (Washington, DC : American Chemical Society Publications., )

Labeled as emerging organic contaminants, pharmaceuticals and personal care products (PPCPs) have been the focus of global environmental research for over a decade. PPCPs have caused widespread concern due to their extensive ...
Discovery and development of unique small molecule chromene based ligands and combretastatin analogs as potential second generation vascular disrupting agents towards cancer chemotherapy.

Arthasery, Phyllis.

Cancer is a devastating disease, which remains one of the leading causes of death worldwide. In our continuing quest to help find a cure for cancer, we have discovered and developed new small molecule vascular disrupting ...
Discovery of a novel adenosine 5'-phosphosulfate (APS) reductase from the methanarcheon Methanocaldococcus jannaschii.

Lee, Jong-Sun, 1979- (Elsevier, )

This thesis presents the first discovery of adenosine 5'-phosphosulfate reductase (APR), a key enzyme of the sulfate reduction pathway, in the methanarchaeon Methanocaldococcus jannaschii. While the sulfate reduction pathway ...
Discovery of DNA-enzymes dependent on small-molecule cofactors; design, synthesis and evaluation of TLR-7 agonists and their immunoprotein conjugates.

Romero, José Roberto Boquín.

Several catalytic families of DNA enzymes (deoxyribozymes) have previously been isolated through the use of an in vitro selection technique in our laboratory. The activities of these deoxyribozymes appear to be dependent ...
Electrochemistry and electron transfer induced substitution reactions of methylcyclopentadienylmolybdenum tricarbonyl complexes and electrospray ionization mass spectrometry and x-ray crystallographic characterization of related molybdenum complexes.

Munisamy, Thiruvengadam. (Oxford, UK : Elsevier, )

The complexes Cp'Mo(CO)3X (X = Cl, Br, I; Cp' = C5H4CH3) and [Cp'Mo(CO)3(L)]+ (L = CH3CN, CH3COCH3) were synthesized and their electrochemistry and electron transfer induced substitution reactions were studied. Electrochemical ...
Fueling advances in ultra performance liquid chromatography – and ion mobility – mass spectrometry as platforms for x-omic analyses.

Munisamy, Sharon Michelle. (, )

Analysis of x-omics samples presents a significant challenge to analytical chemists. The complexity and diversity of x-omics samples make it difficult to determine or develop the right analytical approach. This dissertation ...