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Synthesis of protected amino thymidines and new thiol derivatives of the vascular targeting agent combretastatin A-4.

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dc.contributor.advisor Kane, Robert R.
dc.contributor.author Ramirez, Daniel A.
dc.contributor.other Baylor University. Dept. of Chemistry and Biochemistry. en
dc.date.copyright 2006-12
dc.identifier.uri http://hdl.handle.net/2104/5008
dc.description.abstract Protected amino thymidines were synthesized as part of a project aimed at developing reagents for the site-specific, sequence selective DNA cleavage. Modified DNA oligonucleotides have the capacity to behave like artificial restriction enzymes in addition to being agents for the targeted scission of DNA and RNA in antiviral and gene therapy. Sulfur-containing analogues of the vascular targeting agent (VTA) Combretastatin A4 (CA4) were also synthesized. Vascular targeting agents are a class of anticancer compounds made to target and restrict tumor neovasculature. Disruption of these new tumor-associated capillaries prevents the blood flow necessary to feed the tumor, resulting in tumor cell starvation, the build-up of toxins, and massive necrotic cell death. One of the best characterized small molecule vascular targeting agents is Combretastatin A-4 (CA4), which is currently in Phase II clinical trials. en
dc.rights Baylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission. en
dc.subject Antineoplastic agents -- Synthesis. en
dc.subject Antineoplastic agents -- Analysis. en
dc.subject Tubulins. en
dc.title Synthesis of protected amino thymidines and new thiol derivatives of the vascular targeting agent combretastatin A-4. en
dc.type Thesis en
dc.description.degree M.S. en
dc.rights.accessrights Worldwide access en
dc.contributor.department Chemistry and Biochemistry. en


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