BEARdocs

The role of spectrin in Drosophila photoreceptor development.

DSpace/Manakin Repository

Show simple item record

dc.contributor.advisor Nam, Sang-Chul.
dc.contributor.author Chen, Tony W.
dc.contributor.other Baylor University. Dept. of Biology. en
dc.date.copyright 2008-08
dc.identifier.uri http://hdl.handle.net/2104/5209
dc.description.abstract Spectrin is a cytoskeletal protein that interacts with the plasma membrane, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In Drosophila, spectrin is composed of 3 subunits: α-spectrin, β-spectrin, and βH-spectrin. The interaction between them is important in generating the different polarized membranes in the cell. This study identified the specific effects of spectrin on Drosophila photoreceptor development. In fruit flies the mosaic technique can be used to express both the mutant and the wild-type tissue in a single eye. The mosaic eyes were dissected, fixed, and mounted onto a slide and analyzed using confocal microscopy. Specific roles of α-spectrin, β-spectrin, and βH-spectrin in photoreceptor development were identified and analyzed. This analysis can lead to the identification of the functions of spectrin in photoreceptor development, and to the potential function of spectrin in vertebrate eye development and in causing certain retinal diseases. en
dc.rights Baylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission. en
dc.subject Spectrin -- Analysis. en
dc.subject Drosophila. en
dc.subject Photoreceptors. en
dc.subject Developmental biolgy. en
dc.title The role of spectrin in Drosophila photoreceptor development. en
dc.type Thesis en
dc.description.degree M.S. en
dc.rights.accessrights Worldwide access en
dc.contributor.department Biology. en


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search BEARdocs


Advanced Search

Browse

My Account

Statistics