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To giveth and taketh away : determination of taurine's protective role during ethanol withdrawal through supplementation and depletion paradigms.

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dc.contributor.advisor Diaz-Granados, Jamie L.
dc.contributor.author Zalud, André W.
dc.contributor.other Baylor University. Institute of Biomedical Studies. en
dc.date.copyright 2008-12
dc.identifier.uri http://hdl.handle.net/2104/5295
dc.description.abstract The β-amino acid taurine, whose primary physiological roles involve osmoregulation and calcium modulation, exists as one of the most concentrated amino acids in the mammalian brain. As a neuroinhibitor and neuromodulator, taurine may provide a unique therapeutic approach in reducing the aversive symptoms of ethanol withdrawal that often promote further ethanol abuse. Taurine’s properties could efficiently defend sensitive neural tissues from disturbances of osmolarity and excitability, which typically manifest during episodes of ethanol withdrawal. This investigation examined taurine’s influence on ethanol withdrawal by testing the effects of both taurine treatment and taurine depletion on withdrawal-related convulsions, as well as associated neurochemical alterations in brain tissue. Results showed that taurine, administered during ethanol withdrawal, significantly reduced overall withdrawal severity in adult male C3H/HeJ mice. Conversely, significantly reduced tissue taurine levels, achieved via the taurine uptake inhibitor guanidinoethane sulfonate (GES), exacerbated the severity of ethanol withdrawal. Analysis of extracted tissues (pituitary, supraoptic nucleus of the hypothalamus, and hippocampus) suggests that taurine’s capacity to reduce withdrawal-related convulsions may result from an attenuated release of arginine vasopressin from both the pituitary and supraoptic nucleus. During ethanol withdrawal, conditions of over-hydration can lead to lower hippocampal osmolarities, which itself can produce hyperexcitable states. By inhibiting over-activated vasopressin outflow during withdrawal, taurine seemingly prevents systemic osmotic disruptions that would otherwise disturb osmolarities within sensitive hippocampal tissues. During ethanol withdrawal, treatment with exogenous taurine provides a significant reduction in withdrawal severity and may facilitate the recovery from alcoholism. Given that the current findings also reveal that taurine depletion severely aggravates the severity of ethanol withdrawal, both behaviorally and biochemically, alcohol recovery programs should consider the potential therapeutic benefits of taurine supplementation in treatment regimens. en
dc.rights Baylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission. en
dc.subject Alcoholism -- Treatment. en
dc.subject Alcohol withdrawal syndrome -- Treatment. en
dc.subject Alcohol -- Physiological effect. en
dc.subject Alcohol -- Metabolic detoxication. en
dc.subject Taurine -- Physiological effect. en
dc.title To giveth and taketh away : determination of taurine's protective role during ethanol withdrawal through supplementation and depletion paradigms. en
dc.type Thesis en
dc.description.degree Ph.D. en
dc.rights.accessrights Worldwide access. en
dc.rights.accessrights Access changed 5/24/11.
dc.contributor.department Biomedical Studies. en


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