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Chemical toxicity distributions in aquatic toxicology : relative sensitivities of estrogenicity assays and ecotoxicity of parabens in model freshwater organisms.

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dc.contributor.advisor Brooks, Bryan W.
dc.contributor.author Dobbins, Laura L.
dc.contributor.other Baylor University. Dept. of Biology. en
dc.date.copyright 2009-05
dc.identifier.citation Dobbins, Laura L., Richard A. Brain, and Bryan W. Brooks. "Comparison of the sensitivities of common in vitro and in vivo assays of estrogenic activity : application of chemical toxicity distributions." Environmental Toxicology and Chemistry 27, no. 12 (2008): 2608-2616. en
dc.identifier.uri http://hdl.handle.net/2104/5350
dc.description.abstract A probabilistic ecological hazard assessment technique, chemical toxicity distributions, was used to examine the relative sensitivities of in vitro and in vivo assays for detecting estrogenicity, and to assess the hazards associated with parabens to model aquatic organisms, Pimephales promelas and Daphnia magna. Parabens represent a class of understudied personal care products with estrogenic activity that have been detected in surface waters. MCF-7 and rainbow trout vitellogenin induction were found to be the most sensitive in vitro and in vivo assays of estrogenicity, respectively. Parabens were determined to not pose a hazard to aquatic organisms at levels that are environmentally relevant, based on the bioassay endpoints evaluated. A screening level assessment further identified estrogenic activity of select parabens to adult male P. promelas. This thesis demonstrated the utility of chemical toxicity distributions for determining sensitivities among toxicological models and for assessing those compounds for which environmental exposure data are limited. en
dc.rights Baylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission. en
dc.subject Ecological risk assessment. en
dc.subject Water quality bioassay. en
dc.subject Fresh water organisms -- Effect of water pollution on. en
dc.subject Estrogen -- Environmental aspects. en
dc.subject Estrogen -- Toxicity testing -- In vitro. en
dc.subject Estrogen -- Toxicity testing -- In vivo. en
dc.subject Water -- Pollution -- Toxicology. en
dc.title Chemical toxicity distributions in aquatic toxicology : relative sensitivities of estrogenicity assays and ecotoxicity of parabens in model freshwater organisms. en
dc.type Thesis en
dc.description.degree M.S. en
dc.rights.accessrights Baylor University access only en
dc.contributor.department Biology. en


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