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Effects of eight weeks of curcumin and Boswellia serrata supplementation on plasma markers of inflammation and antioxidant activity in chronic kidney disease patients.

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dc.contributor.advisor Bowden, Rodney G., 1966-
dc.contributor.advisor Cooke, Matthew B.
dc.contributor.author Moreillon, Jennifer Josephine.
dc.contributor.other Baylor University. Dept. of Health, Human Performance and Recreation. en
dc.date.copyright 2010-08
dc.identifier.uri http://hdl.handle.net/2104/8045
dc.description.abstract The purpose of this study was to examine the effects of 8 weeks of curcumin and Bowellia serrata supplementation on changes in systemic inflammation and antioxidant activity in chronic kidney disease (CKD) patients. Sixteen CKD patients (56.0 ± 16.0 years, 171.4 ± 11.9 cm, 99.3 ± 20.2 kg) were randomized in a double blind fashion to ingest a daily supplement composed of 1340 mg of curcumin and Boswellia serrata (824 mg purified turmeric extract, 95% curcuminoids and 516 mg Boswellia serrata extract, 10% 3-acetyl-11-keto-beta-Boswellic acid) or 1340 mg of a roasted rice powder placebo. Patients provided fasting blood samples pre- and post-supplementation in order to assess changes in systemic inflammation and antioxidant activity. A 2 x 2 repeated measures MANCOVA with a probability level of 0.05 was used for the statistical analysis. No significant changes (p > 0.05) were observed for the indicators of inflammation, represented by plasma interleukin-6 and plasma tumor necrosis factor-alpha, as well as the indicator of antioxidant activity represented by plasma glutathione peroxidase. It appears that 8 weeks of curcumin and Boswellia serrata supplementation does not affect inflammation levels and antioxidant activity in CKD patients. More research is needed to determine the impact that curcumin and Boswellia serrata supplementation have on changes in inflammation and antioxidant activity in diseased populations. en
dc.rights Baylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission. en
dc.subject Chronic kidney disease. en
dc.subject Curcumin. en
dc.subject Boswellia serrata. en
dc.title Effects of eight weeks of curcumin and Boswellia serrata supplementation on plasma markers of inflammation and antioxidant activity in chronic kidney disease patients. en
dc.type Thesis en
dc.description.degree Ph.D. en
dc.rights.accessrights Worldwide access. en
dc.rights.accessrights Access changed 3/18/13.
dc.contributor.department Health, Human Performance and Recreation. en


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