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PKCγ expression in adolescent and adult rats : evidence for a cerebellar mechanism underlying age-dependent motor impairments produced by acute ethanol.

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dc.contributor.advisor Diaz-Granados, Jamie L.
dc.contributor.advisor Matthews, Douglas B.
dc.contributor.author Van Skike, Candice E.
dc.contributor.other Baylor University. Dept. of Psychology and Neuroscience. en
dc.date.copyright 2011-05
dc.identifier.citation Van Skike, C. E., Botta, P., Chin, V. S., Tokunaga, S., McDaniel, J. M., Venard, J., Diaz-Granados, J. L., Valenzuela, C. F., Matthews, D. B. "Behavioral effects of ethanol in cerebellum are age dependent : potential system and molecular mechanisms." Alcoholism : Clinical and Experimental Research 32, 12 (2010): 2070-2080. en
dc.identifier.uri http://hdl.handle.net/2104/8175
dc.description.abstract Adolescents are less sensitive to ethanol-induced motor impairments compared to adults; however, a definitive mechanism underlying this difference has not been identified. Compared to wild-type littermates, PKCγ knock-out mice exhibit reduced motor sensitivity to ethanol; it is plausible that adolescent rats also have reduced PKCγ expression in brain regions responsible for motor function, specifically the cerebellum and cortex. Reduced PKCγ expression in these regions may govern the age-dependent motor impairments produced by ethanol. The current study analyzed membrane-bound PKCγ expression in adolescent and adult rats 40 minutes after an acute ethanol or saline injection. Western blot analysis indicates adolescent rats have reduced PKCγ expression in the cerebellum and cortex compared to adults. It is concluded that PKCγ expression may be part of a larger mechanism regulating the age-dependent motor impairments produced by acute ethanol administration. en
dc.publisher John Wiley & Sons. en
dc.rights Baylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission. en
dc.subject Adolescence. en
dc.subject Alcohol. en
dc.subject Protein Kinase C. en
dc.subject Ethanol-induced motor impairments. en
dc.subject Cerebellum. en
dc.title PKCγ expression in adolescent and adult rats : evidence for a cerebellar mechanism underlying age-dependent motor impairments produced by acute ethanol. en
dc.type Thesis en
dc.description.degree M.A. en
dc.rights.accessrights Worldwide access en
dc.contributor.department Psychology and Neuroscience. en


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