Synergistic Effects of Hydroxychloroquine on the Activity of Thiomaltol against Melanoma Cancer Cells

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dc.contributor.advisor Farmer, Patrick Sartor, Zachary
dc.contributor.other Baylor University en_US
dc.contributor.other Texas A&M Health Sciences Center College of Medicine- Newell Research Laboratory en_US 2012
dc.description.abstract Although melanoma accounts for a very small percentage of all skin cancer cases, it is the most responsible for skin cancer related deaths. Therapeutic agents that induce apoptosis in the cancer cells have been heavily researched. Some recent research has focused on enhancing the effects of apoptotic agents by blocking autophagy, a cancer survival mechanism where the cells digest themselves. Research has shown that inhibiting this pathway with certain drugs can lead to cell death at a greater rate than by using apoptosis inducing agents alone. However, the universal application of blocking autophagy is debated by most researchers. The main question this study seeks to answer is whether the effects of an autophagy blocking agent used alongside an apoptosis inducing drug will increase cell death at levels higher than using the drug alone. The apoptotic drug used is thiomaltol (Htma). The autophagy blocking agent used is hydroxychloroquine (HCQ). The two compounds are tested against B16F1 melanoma cells from mice. Overall, data indicates that although the activity of Htma in these cells is not as high compared to other cell lines, there is an increase in cell death when both Htma and HCQ are administered. This increase in activity is higher when the compounds are administered over an extended period of time. en_US
dc.rights Baylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact for inquiries about permission. en_US
dc.subject melanoma en_US
dc.subject autophagy en_US
dc.subject apoptosis en_US
dc.title Synergistic Effects of Hydroxychloroquine on the Activity of Thiomaltol against Melanoma Cancer Cells en_US
dc.type Thesis en_US
dc.rights.accessrights Worldwide access en_US
dc.contributor.department Chemistry and Biochemistry en_US
dc.contributor.schools honors college en_US

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