Cobalt(III), Chromium(III), Glutathione, and Their Relevance to the Glucose Tolerance Factor

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dc.contributor.advisor Pennington, David Naumann, Matthew
dc.contributor.other Baylor University. en_US 2012
dc.description.abstract The so-called glucose tolerance factor (GTF) is believed to be a biological complex of chromium that works alongside insulin to enhance the body’s ability to metabolize sugar. Chromium and cobalt complexes with glutathione were synthesized as potential analogues to the GTF. These were then analyzed via mass spectrometry and UV-visible absorption for potential clues to the composition and connectivity of the complexes. Upon analysis, the cobalt complex with glutathione appeared to have an uncoordinated sulfhydryl group, consistent with the hypothesis that the GTF interacts with the insulin receptor via a sulfhydryl-disulfide exchange. Such a complex could theoretically be tested for GTF activity. en_US
dc.rights Baylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact for inquiries about permission. en_US
dc.subject Coordination chemistry. en_US
dc.subject Glucose tolerance factor. en_US
dc.subject Cobalt(III). en_US
dc.subject Chromium(III). en_US
dc.subject Glutathione. en_US
dc.title Cobalt(III), Chromium(III), Glutathione, and Their Relevance to the Glucose Tolerance Factor en_US
dc.type Thesis en_US
dc.rights.accessrights Worldwide access en_US
dc.contributor.department Chemistry and Biochemistry en_US
dc.contributor.schools honors college en_US

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