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Regulation of Anxiety and Alcohol Drinking Behavior by Neuropeptide Y and Corticotropin-Releasing Hormone in the Central Nucleus of the Amygdala

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dc.contributor.advisor Keele, N. Bradley
dc.contributor.author Peña, Adrian I.
dc.contributor.other Baylor University. en_US
dc.date.copyright 2012-05-04
dc.identifier.uri http://hdl.handle.net/2104/8389
dc.description.abstract The rising consumption of alcohol in Western societies and subsequent alcoholrelated life problems that develop has been labeled a major health and social issue. Finding an effective treatment for alcohol dependence has been faced with difficulty, as this is a complex phenomenon that has its roots in a variety of factors. Anxiety and stress have a strong correlation with alcohol intake behavior, and cyclic bouts of alcohol drinking and withdrawal lead to enhanced anxiety reactivity. Recently, two neuromodulators have been implicated in the regulation of anxiety and ensuing alcohol intake: neuropeptide Y (NPY) and corticotropin releasing hormone (CRH) both of which exert their effects on the central nucleus of the amygdala (CeA), a structure implicated in anxiety disorders. This review examines how these two neuromodulators interact, the cellular and molecular mechanisms by which they exert their effects, how these mechanisms affect neuronal excitability within the CeA, and how ethanol relates to both NPY and CRH which will hopefully answer questions with regards to the neurophysiology of alcohol intake behavior. en_US
dc.rights Baylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission. en_US
dc.subject Neuropeptide Y. en_US
dc.subject Alcohol dependence. en_US
dc.subject Stress and anxiety. en_US
dc.subject Amygdala hyperexcitability. en_US
dc.subject Literature review. en_US
dc.title Regulation of Anxiety and Alcohol Drinking Behavior by Neuropeptide Y and Corticotropin-Releasing Hormone in the Central Nucleus of the Amygdala en_US
dc.type Thesis en_US
dc.rights.accessrights Worldwide access en_US
dc.contributor.department Psychology and Neuroscience en_US
dc.contributor.schools honors college en_US


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