BEARdocs

Using in vitro to in vivo extrapolation (IVIVE) to develop toxicity metrics for human health risk assessment of polybrominated diphenyl ethers (PBDEs).

DSpace/Manakin Repository

Show simple item record

dc.contributor.advisor Bruce, Erica Dawn.
dc.contributor.author Pree, Krystal.
dc.date.copyright 2012-08
dc.identifier.uri http://hdl.handle.net/2104/8512
dc.description.abstract Polybrominated diphenyl ethers (PBDEs) are flame retardants found in many industrial components, such as furniture foam, consumer electronics, plastics, and textiles and levels have increased in humans over the past few decades. PBDEs demonstrate adverse neurotoxic effects in mice, are lipophilic, and bioaccumulate in fish. Consequently, PBDE biomagnification may occur, which can be transferred to humans in amounts that may present adverse health effects. This investigation uses in vitro models to calculate bioassay-based reference doses in order to develop a human health risk assessment based on the consumption of PBDE-contaminated fish, using in vitro to in vivo extrapolation (IVIVE). The toxicity effects of ten PBDE congeners were examined and compared among those developed using traditional in vivo mice studies and in vitro models in this study using rat (Clone-9), HEPG2 and zebrafish liver cells to determine the feasibility of using alternative approaches to develop toxicity metrics to evaluate human health risk. en_US
dc.publisher en
dc.rights Baylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission. en_US
dc.subject Human health risk assessment. en_US
dc.subject In vitro to in vivo extrapolation (IVIVE). en_US
dc.subject Toxicity metrics. en_US
dc.subject Polybrominated diphenyl ethers (PBDEs). en_US
dc.title Using in vitro to in vivo extrapolation (IVIVE) to develop toxicity metrics for human health risk assessment of polybrominated diphenyl ethers (PBDEs). en_US
dc.type Thesis en_US
dc.description.degree M.S. en_US
dc.rights.accessrights Worldwide access. en_US
dc.rights.accessrights Access changed 1/14/14.
dc.contributor.department Environmental Science. en_US
dc.contributor.schools Baylor University. Dept. of Environmental Science. en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search BEARdocs


Advanced Search

Browse

My Account

Statistics